Following the success of her 2 short films – Wax Hurts (2001) and Visiting Hours (2005) – in Cannes IFF,  Dreifuss had completed her debut feature She Is Coming Home (2013). The film won Best First Feature Film Award, Best Actress Award and Best Cinematography Award at the Jerusalem IFF and Best Female Supporting Role Award at the Israeli Academy Awards.

In 2016  she co-created and artistically directed Heroine, a  film comprising five shorts, written and directed by female directors. Maya was the script editor of the 2016 Sundance Grand Jury Award-winning Sand Storm. Highway 65 is  her second feature film. It was nominated for 9 Israeli academy awards and won the big prize at the reins polar thriller film festival, france. Maya is a senior professor and head of production department in the Steve Tish Film & Television School, Tel Aviv University.